uu.seUppsala University Publications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
The CHEK2 1100delC variant in Swedish colorectal cancer
Show others and affiliations
2006 (English)In: Anticancer Research, ISSN 0250-7005, E-ISSN 1791-7530, Vol. 26, no 6C, 4885-4888 p.Article in journal (Refereed) Published
Abstract [en]

Background: The cell cycle checkpoint kinase 2 (CHEK2) 1100delC variant has recently been identified at high frequency in families with both breast and colorectal cancer, suggesting the possible role of this variant in colorectal cancer predisposition. Patients and Methods: To evaluate the role of CHEK2 1100delC among Swedish colorectal cancer patients, the variant frequency was determined in 174 selected familial cases, 644 unselected cases and 760 controls, as well as in 18 families used in the genome-wide linkage analysis, where weak linkage was seen for the region harboring the CHEK2 gene. Results: CHEK2 1100delC was found in 1.15% of familial and in 0.93% of unselected cases, compared to 0.66% of controls, showing no significant difference between groups. One out of 45 familial cases with a family history of breast cancer was shown to be a carrier. The variant was not identified in the 18 families included in the linkage analysis. Conclusion: The CHEK2 1100delC was not significantly increased in Swedish colorectal cancer patients, however, in order to determine the role of the variant in colorectal cancer families with the history of breast cancer a larger sample size is needed.

Place, publisher, year, edition, pages
2006. Vol. 26, no 6C, 4885-4888 p.
Keyword [en]
CHEK2, colorectal cancer
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-11843ISI: 000243083600038PubMedID: 17214356OAI: oai:DiVA.org:uu-11843DiVA: diva2:39612
Available from: 2007-10-26 Created: 2007-10-26 Last updated: 2017-12-11Bibliographically approved

Open Access in DiVA

No full text

PubMed

Authority records BETA

Påhlman, Lars

Search in DiVA

By author/editor
Påhlman, Lars
By organisation
Department of Surgical Sciences
In the same journal
Anticancer Research
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar

pubmed
urn-nbn

Altmetric score

pubmed
urn-nbn
Total: 357 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf