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Radiological Contrast Media and Pancreatic Blood Perfusion in Anesthetized Rats
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Cell Biology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Cell Biology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Cell Biology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Cell Biology.
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2007 (English)In: Acta Radiologica, ISSN 0284-1851, E-ISSN 1600-0455, Vol. 48, no 10, 1120-1124 p.Article in journal (Refereed) Published
Abstract [en]

Background: Radiological contrast media (CM) have been suggested to be able to impair pancreatic microcirculation. Purpose: To evaluate the effects of an iso-osmolar (iodixanol, 290 mOsm/kg H2O) and a low-osmolar (iopromide, 660 mOsm/kg H2O) CM on total pancreatic and islet blood perfusion. Material and Methods: Thiobutabarbital-anesthetized rats were injected with iodine-equivalent doses (600 mg I/kg body weight) of iodixanol or iopromide. Saline or low-osmolar mannitol (660 mOsm/kg H2O) solutions served as control substances. Blood perfusion measurements were then carried out with a microsphere technique. Results: Iso-osmolar iodixanol had no effects on blood perfusion. Low-osmolar iopromide increased total pancreatic blood perfusion, whereas islet blood perfusion was unchanged. No differences were seen when mannitol solutions were given. Conclusion: Neither an iso-osmolar nor a low-osmolar CM affected pancreatic islet blood perfusion, whereas the low-osmolar CM increased total pancreatic blood perfusion. The absence of hemodynamic effect of low-osmolar mannitol suggests that the hyperosmolality per se of iopromide versus iodixanol does not induce the hemodynamic effect. The consequences of the effect of iopromide for pancreatic function remain to be established.

Place, publisher, year, edition, pages
2007. Vol. 48, no 10, 1120-1124 p.
Keyword [en]
Intravascular contrast agents, islet blood perfusion, pancreatic blood perfusion
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-11854DOI: 10.1080/02841850701611102ISI: 000251240400012PubMedID: 17963084OAI: oai:DiVA.org:uu-11854DiVA: diva2:39623
Available from: 2007-10-29 Created: 2007-10-29 Last updated: 2017-12-11Bibliographically approved

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