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Association of a Haplotype in the Promoter Region of the Interferon Regulatory Factor 5 Gene With Rheumatoid Arthritis
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences.
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2007 (English)In: Arthritis and Rheumatism, ISSN 0004-3591, E-ISSN 1529-0131, Vol. 56, no 7, 2202-2210 p.Article in journal (Refereed) Published
Abstract [en]

Objective. To determine whether genetic variants of the interferon regulatory factor 5 (IRF-5) and Tyk-2 genes are associated with rheumatoid arthritis (RA). Methods. Five single-nucleotide polymorphisms (SNPs) in IRF5 and 3 SNPs in Tyk2 were analyzed in a Swedish cohort of 1,530 patients with RA and 881 controls. A replication study was performed in a Dutch cohort of 387 patients with RA and 181 controls. All patient sera were tested for the presence of autoantibodies against cyclic citrullinated peptides (anti-CCP). Results. Four of the 5 SNPs located in the 5' region of IRF5 were associated with RA, while no association was observed with the Tyk2 SNPs. The minor alleles of 3 of the IRF5 SNPs, which were in linkage disequilibrium and formed a relatively common haplotype with a frequency of ∼0.33, appeared to confer protection against RA. Although these disease associations were seen in the entire patient group, they were mainly found in RA patients who were negative for anti-CCP. A suggestive association of IRF5 SNPs with anti-CCP-negative RA was also observed in the Dutch cohort. Conclusion. Given the fact that anti-CCP-negative RA differs from anti-CCP-positive RA with respect to genetic and environmental risk factor profiles, our results indicate that genetic variants of IRF5 contribute to a unique disease etiology and pathogenesis in anti-CCP-negative RA.

Place, publisher, year, edition, pages
2007. Vol. 56, no 7, 2202-2210 p.
Keyword [en]
Immunopathology, Diseases of the osteoarticular system, Inflammatory joint disease, Autoimmune disease, Cytokine, Chronic, Rheumatoid factor, Interferon, Promoter, Haplotype, Autoimmunity, Rheumatoid arthritis
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-11887DOI: 10.1002/art.22704ISI: 000248071600012PubMedID: 17599733OAI: oai:DiVA.org:uu-11887DiVA: diva2:39656
Available from: 2008-01-28 Created: 2008-01-28 Last updated: 2011-03-25Bibliographically approved

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Sigurdsson, SnaevarLiljedahl, UlrikaRönnelid, JohanAlm, GunnarSyvänen, Ann-ChristineRönnblom, Lars
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Department of Medical SciencesDepartment of Oncology, Radiology and Clinical Immunology
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