uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Expression pattern of JunD after acute or chronic L-DOPA treatment: comparison with deltaFosB.
Lund Universitet. (Neurobiologi)
2007 (English)In: Neuroscience, ISSN 0306-4522, E-ISSN 1873-7544, Vol. 144, no 1, 198-207 p.Article in journal (Refereed) Published
Abstract [en]

In this study, we have used 6-hydroxydopamine-lesioned rats to examine changes in striatal junD and fosB/deltafosB expression induced by acute and chronic treatment with L-DOPA (5 and 15 days). Changes at the protein levels were studied using Western immunoblotting while mRNA changes were compared using in situ hybridization histochemistry. We observed a significant increase in the level of deltaFosB proteins after chronic treatment with L-DOPA, an effect that was not observed for JunD proteins. In addition, the upregulation of deltaFosB was already present after an acute treatment but increased upon chronic treatment. By contrast, junD and deltafosB mRNA were both upregulated significantly above control levels after an acute injection of L-DOPA. In conclusion, this study suggests a differential expression pattern of junD and deltafosB in a rat model of L-DOPA-induced dyskinesia. The upregulation of deltaFosB protein, but not JunD, is likely to reflect an increased stability of the deltaFosB proteins without ongoing enhanced transcription of the encoding genes.

Place, publisher, year, edition, pages
2007. Vol. 144, no 1, 198-207 p.
URN: urn:nbn:se:uu:diva-145672DOI: 10.1016/j.neuroscience.2006.09.001PubMedID: 17055656OAI: oai:DiVA.org:uu-145672DiVA: diva2:396576
Available from: 2011-02-10 Created: 2011-02-10 Last updated: 2011-02-10

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed
In the same journal

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 134 hits
ReferencesLink to record
Permanent link

Direct link