Flexibility Description of the MET Protein Stalk Based on the Use of Non-Uniform B-Splines
2007 (English)In: 12th International Conference on Computer Analysis of Images and Patterns, 2007, 173-180 p.Conference paper (Refereed)
The MET protein controls growth, invasion, and metastasis in cancer cells and is thereby of interest to study, for example from a structural point of view. For individual particle imaging by Cryo-Electron Tomography of the MET protein, or other proteins, dedicated image analysis methods are required to extract information in a robust way as the images have low contrast and resolution (with respect to the size of the imaged structure). We present a method to identify the two parts of the MET protein, Beta-propeller and stalk, using a fuzzy framework. Furthermore, we describe how a representation of the MET stalk, denoted stalk curve, can be identified based on the use of non-uniform B-splines. The stalk curve is used to extract relevant geometrical information about the stalk, e.g., to facilitate curvature and length measurements.
Place, publisher, year, edition, pages
2007. 173-180 p.
Cryo-ET, fuzzy distance, geometrical feature extraction
IdentifiersURN: urn:nbn:se:uu:diva-11902DOI: doi:10.1007/978-3-540-74272-2_22ISBN: 978-3-540-74271-5OAI: oai:DiVA.org:uu-11902DiVA: diva2:39671