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Activation of growth factor receptors in esophageal cancer: implications for therapy
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Oncology, Radiology and Clinical Immunology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Oncology, Radiology and Clinical Immunology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm , Ludwig Institute for Cancer Research.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm , Ludwig Institute for Cancer Research.
2007 (English)In: The Oncologist, ISSN 1083-7159, E-ISSN 1549-490X, Vol. 12, no 10, 1165-1177 p.Article, review/survey (Refereed) Published
Abstract [en]

Esophageal cancer is a highly aggressive disease and is the seventh most common cause of cancer-related death in the western world. Worldwide, it ranks as the sixth most frequent cause of cancer death. Despite advances in surgical techniques and treatment, the prognosis of esophageal cancer remains poor, with very few long-term survivors. The need for novel strategies to detect esophageal cancer earlier and to improve current therapy is urgent. It is well established that growth factors and growth factor receptor-mediated signaling pathways are important components of the transformation process in many forms of cancer, including esophageal cancer. With the recent advances in drug development, there are emerging possibilities to use growth factor signal transduction pathways in targeted therapy. This review provides a summary of the role of growth factors and their receptors in esophageal cancer and discusses their potential roles as biomarkers and as targets in therapy.

Place, publisher, year, edition, pages
2007. Vol. 12, no 10, 1165-1177 p.
Keyword [en]
Esophageal squamous cancer, Targeted therapy, Growth factor receptors, Esophageal adenocarcinoma
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-11913DOI: 10.1634/theoncologist.12-10-1165ISI: 000250773000002PubMedID: 17962610OAI: oai:DiVA.org:uu-11913DiVA: diva2:39682
Available from: 2007-11-06 Created: 2007-11-06 Last updated: 2017-12-11Bibliographically approved

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Bergqvist, MichaelHeldin, Carl-HenrikLennartsson, Johan

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