Co-loading of bisphosphonates and antibiotics to a biomimetic hydroxyapatite coating
2011 (English)In: Biotechnology letters, ISSN 0141-5492, E-ISSN 1573-6776, Vol. 33, no 6, 1265-1268 p.Article in journal (Refereed) Published
We have incorporated bisphosphonates and antibiotics simultaneously into a biomimetic hydroxyapatite implant coating aiming to use the interaction between drug-molecules and hydroxyapatite to enable local release of the two different substances to obtain a dual biological effect. A sustained release over for 43 h of antibiotics (cephalothin) was achieved without negative interference from the presence of the bisphosphonate (clodronate) which, in turn, successfully bonded to the coating surface. To our knowledge, this is the first study that indicates the possibility to simultaneously incorporate both antibiotics and bisphosphonates to an implant coating, a strategy that is believed to improve implant stability and reduce implant-related infections.
Place, publisher, year, edition, pages
2011. Vol. 33, no 6, 1265-1268 p.
Nano Technology Medical Biotechnology
Research subject Engineering Science with specialization in Nanotechnology and Functional Materials
IdentifiersURN: urn:nbn:se:uu:diva-145824DOI: 10.1007/s10529-011-0542-7ISI: 000291655200027PubMedID: 21287232OAI: oai:DiVA.org:uu-145824DiVA: diva2:396971