Backbone carbonyl group basicities are related to gas-phase fragmentation of peptides and protein folding
2007 (English)In: Angewandte Chemie International Edition, ISSN 1433-7851, E-ISSN 1521-3773, Vol. 46, no 9, 1481-1484 p.Article in journal (Refereed) Published
A strong correlation is found between the propensity of individual amino acids to induce peptide-bond cleavage in the gas phase (PAA-XX) and their structure-forming propensity (PS, red) and H-bond-accepting propensity (PH, blue). Thus, the same fundamental parameter, carbonyl group basicity, governs the formation of secondary protein structures in solution and directs fragmentation in the gas phase. (Graph Presented).
Place, publisher, year, edition, pages
2007. Vol. 46, no 9, 1481-1484 p.
hydrogen bonds, mass spectrometry, peptide fragmentation, protein structures, proteomics
IdentifiersURN: urn:nbn:se:uu:diva-145840DOI: 10.1002/anie.200603881ISI: 000244507100023PubMedID: 17211901OAI: oai:DiVA.org:uu-145840DiVA: diva2:397027