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Image Processing System for Localising Macromolecules in Cryo-Electron Tomography
Uppsala University, Disciplinary Domain of Science and Technology, Mathematics and Computer Science, Centre for Image Analysis. Uppsala University, Disciplinary Domain of Science and Technology, Mathematics and Computer Science, Department of Information Technology, Computerized Image Analysis.
Okinawa Institute of Science and Technology, Okinawa, Japan.
Okinawa Institute of Science and Technology, Okinawa, Japan.
Uppsala University, Disciplinary Domain of Science and Technology, Mathematics and Computer Science, Centre for Image Analysis. Uppsala University, Disciplinary Domain of Science and Technology, Mathematics and Computer Science, Department of Information Technology, Computerized Image Analysis.
2010 (English)In: Machine Graphics & Vision, ISSN 1230-0535, Vol. 19, no 2, 159-184 p.Article in journal (Refereed) Published
Abstract [en]

A major challenge in today's molecular biology research is to understand the interaction between proteins at the molecular level. Cryo-electron tomography (ET) has come to play an important role in facilitating objective qualitative experiments on protein structures and their interaction. Various protein conformation structures can be qualitatively analysed as complete galleries of proteins are captured by ET. To facilitate fast and objective macromolecular structure analysis procedures, image processing has become a crucial tool. This paper presents an image processing system for localising individual proteins from in vitro samples imaged by ET. We have evaluated the system using simulated data as well as experimental data.

Place, publisher, year, edition, pages
Warsaw, Poland: Institute of Computer Science, Polish Academy of Science , 2010. Vol. 19, no 2, 159-184 p.
National Category
Engineering and Technology
Research subject
Computerized Image Analysis
Identifiers
URN: urn:nbn:se:uu:diva-145830OAI: oai:DiVA.org:uu-145830DiVA: diva2:397073
Available from: 2011-02-11 Created: 2011-02-11 Last updated: 2011-02-15Bibliographically approved

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