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Coxsackievirus B3 infection affects metal-binding/transporting proteins and trace elements in the pancreas in mice
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Oncology, Radiology and Clinical Immunology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical Virology. (Blomberg)
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2007 (English)In: Pancreas, ISSN 0885-3177, E-ISSN 1536-4828, Vol. 35, no 3, e37-e44 p.Article in journal (Refereed) Published
Abstract [en]

Objective: The trigger of juvenile diabetes has been suggested to be an interaction between a virus and trace elements, where enteroviruses, including coxsackievirus B3 (CVB3), have been discussed as potential initiators. The aim of this study was to investigate the effects in the pancreas on gene expressions of metallothionein 1 (MT1), divalent metal transporter 1 (DMT1), and zinc transporter 5 (ZnT-5) and concomitant changes in iron (Fe), copper (Cu), and zinc (Zn) in serum and pancreas of Balb/c mice on days 3, 6, and 9 of CVB3 infection. Methods: Trace elements were measured through inductively coupled plasma-mass spectrometry, and CVB3, MT1, DMT1, and ZnT-5 were measured by reverse transcription/polymerase chain reaction. Results: Virus was found in the pancreas on all days, with a peak on day 3. Infection tended to increase Fe in both serum and the pancreas. The Cu/Zn ratio in the pancreas increased early in the infection because of a great decrease in Zn. In serum, the Cu/Zn ratio was not increased until day 9 of the disease. In the pancreas, MT1 decreased, whereas DMT1 tended to increase on day 6, and ZnT-5 increased progressively during the course of the disease. Conclusions: Virus-induced changes in trace elements, MT1, DMT1, and ZnT-5 in the pancreas may reflect early stages of the development of pancreatitis and prestages of diabetic disease.

Place, publisher, year, edition, pages
2007. Vol. 35, no 3, e37-e44 p.
Keyword [en]
copper, coxsackievirus, MT1, pancreas, zinc, ZnT-5
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-11955DOI: 10.1097/mpa.0b013e3180986e84ISI: 000252179000023PubMedID: 17895834OAI: oai:DiVA.org:uu-11955DiVA: diva2:39724
Available from: 2007-11-07 Created: 2007-11-07 Last updated: 2017-12-11Bibliographically approved

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Frisk, PeterBlomberg, JonasFriman, GöranIlbäck, Nils-Gunnar

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