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Sequential trace element changes in serum and blood during a common viral infection in mice
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Oncology, Radiology and Clinical Immunology, Enheten för metallbiologisk forskning. (Metallbiologisk forskning)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Infectious Diseases. (Sjölin)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical Virology. (Blomberg)
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2007 (English)In: Journal of Trace Elements in Medicine and Biology, ISSN 0946-672X, E-ISSN 1878-3252, Vol. 21, no 1, 29-36 p.Article in journal (Refereed) Published
Abstract [en]

When trace elements are used as diagnostic tools during disease, it is important to know whether the balance is changed in free or bound elements. Although acute infections are associated with changed trace element balance in serum/plasma, it is not known whether changes occur concomitantly in serum and blood. In the present study the human coxsackievirus B3 (CB3), here adapted to Balb/c mice, was used to study whether infection alters the normal physiological trace element balance in blood and serum. Virus was quantitatively measured in two target organs (pancreas and liver) of this infection by reverse transcription polymerase chain reaction (RT-PCR), showing high concentrations of virus proving ongoing infection. Concentrations of 14 elements were measured in whole blood and serum using inductively coupled plasma mass spectrometry (ICP-MS) on days 3, 6 and 9 of the infection. Free and total thyroxine were measured in serum to prove metabolic changes associated with the infection. The thyroxine decreased, while iron and the Cu/Zn ratio in serum increased as a response to the infection. No clear changes in these elements were observed in blood. Cd and Hg tended to decrease in serum but to increase in blood, indicating accumulation in blood cells. Moreover, Al showed a similar decreasing trend in both serum and blood. A correlation between serum and blood levels was observed at different time points of the disease for 9 of the elements. However, As was the only element indicating correlations between serum and blood during the entire course of the disease.

Place, publisher, year, edition, pages
2007. Vol. 21, no 1, 29-36 p.
Keyword [en]
Blood, Serum, Thyroxine, Trace elements, Virus
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-11957DOI: 10.1016/j.jtemb.2006.11.003ISI: 000245350300005PubMedID: 17317523OAI: oai:DiVA.org:uu-11957DiVA: diva2:39726
Available from: 2007-11-07 Created: 2007-11-07 Last updated: 2017-12-11Bibliographically approved

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Frisk, PeterFriman, GöranBlomberg, JonasIlbäck, Nils-Gunnar

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Enheten för metallbiologisk forskningInfectious DiseasesClinical Virology
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