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Significant improvement of eczema with skin care and food elimination in small children.
Uppsala University, Interfaculty Units, Centrum för klinisk forskning, Gävleborg.
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2005 (English)In: Acta Paediatr, ISSN 0803-5253, Vol. 94, no 10, 1384-8 p.Article in journal (Refereed) Published
Abstract [en]

AIM: To evaluate common methods of investigation and treatment in children younger than 2 y of age with eczema, with or without sensitization to food allergens. METHODS: One hundred and twenty-three children younger than 2 y of age with eczema and suspected food allergy were included in this prospective study. The children underwent skin-prick test with cow's milk, fresh hen's egg white and wheat. Specific IgE to milk and egg white was analysed. The eczema extent and severity was estimated with SCORAD before and after treatment. Children with a positive skin-prick test were instructed to exclude that food item from their diet. All children were treated with emollients and topical steroids when needed. RESULTS: Sixty-two of the children were skin-prick positive to at least one of the allergens; 62% had mild, 30% moderate and 8% severe eczema at their first visit. After treatment, 90% had mild, 10% moderate and 0% severe eczema. Forty-six per cent of the children had circulating IgE antibodies to milk or egg white. Ten per cent had specific IgE but negative skin-prick test to the same allergen. This subgroup improved their eczema significantly without elimination diet. CONCLUSION: The conventional treatments for children with eczema, i.e. skin care and food elimination, are effective. The beneficial effect of skin care as the first step should not be neglected, and it may not be necessary to eliminate food allergens to relieve skin symptoms in all food-sensitized children with eczema.

Place, publisher, year, edition, pages
2005. Vol. 94, no 10, 1384-8 p.
Keyword [en]
Antibodies; Anti-Idiotypic/analysis/immunology, Child; Preschool, Cohort Studies, Combined Modality Therapy, Dermatologic Agents/therapeutic use, Diet, Eczema/*diagnosis/immunology/*therapy, Female, Follow-Up Studies, Food Hypersensitivity/*diagnosis/immunology/*therapy, Humans, Immunoglobulin E/analysis/immunology, Infant, Male, Patch Tests, Probability, Prospective Studies, Risk Assessment, Severity of Illness Index, Skin Care/*methods, Statistics; Nonparametric, Treatment Outcome
URN: urn:nbn:se:uu:diva-11969PubMedID: 16299867OAI: oai:DiVA.org:uu-11969DiVA: diva2:39738
Available from: 2007-11-07 Created: 2007-11-07 Last updated: 2011-01-12

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