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Immunohistochemical and Biochemical Studies with Region-Specific Antibodies to Chromogranins A and B and Secretogranins II and III in Neuroendocrine Tumors
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Genetics and Pathology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical Chemistry.
2010 (English)In: Cellular and Molecular Neurobiology, New York, USA: SPRINGER/PLENUM PUBLISHERS , 2010, Vol. 30, no 8, 1147-1153 p.Conference paper (Refereed)
Abstract [en]

This short review deals with our investigations in neuroendocrine tumors (NETs) with antibodies against defined epitopes of chromogranins (Cgs) A and B and secretogranins (Sgs) II and III. The immunohistochemical expression of different epitopes of the granin family of proteins varies in NE cells in normal human endocrine and non-endocrine organs and in NETs, suggesting post-translational processing. In most NETs one or more epitopes of the granins were lacking, but variations in the expression pattern occurred both in benign and malignant NETs. A few epitopes displayed patterns that may be valuable in differentiating between benign and malignant NET types, e.g., well-differentiated NET types expressed more CgA epitopes than the poorly differentiated ones and C-terminal secretoneurin visualized a cell type related to malignancy in pheochromocytomas. Plasma concentrations of different epitopes of CgA and CgB varied. In patients suffering from carcinoid tumors or endocrine pancreatic tumors the highest concentrations were found with epitopes from the mid-portion of CgA. For CgB the highest plasma concentrations were recorded for the epitope 439-451. Measurements of SgII showed that patients with endocrine pancreatic tumors had higher concentrations than patients with carcinoid tumors or pheochromocytomas. SgIII was not detectable in patients with NETs.

Place, publisher, year, edition, pages
New York, USA: SPRINGER/PLENUM PUBLISHERS , 2010. Vol. 30, no 8, 1147-1153 p.
, Cellular and Molecular Neurobiology, ISSN 0272-4340 ; Volume 30, Issue 8
Keyword [en]
Chromogranin A, Chromogranin B, Secretogranin II, Secretogranin III, Neuroendocrine tumor, Immunohistochemistry, Plasma concentration measurements
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-146082DOI: 10.1007/s10571-010-9585-xISI: 000285947200003PubMedID: 21046454OAI: oai:DiVA.org:uu-146082DiVA: diva2:397524
15th International Symposium on Chromaffin Cell Biology Merida, MEXICO, NOV 12-16, 2009
Available from: 2011-02-15 Created: 2011-02-15 Last updated: 2011-02-15Bibliographically approved

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