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Caenorhabditis elegans as a model to determine fitness of antibiotic-resistant Salmonella enterica serovar typhimurium
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology.
2007 (English)In: Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, E-ISSN 1098-6596, Vol. 51, no 2, 766-769 p.Article in journal (Refereed) Published
Abstract [en]

We used the ability of Salmonella enterica serovar Typhimurium to colonize the gut of Caenorhabditis elegans to measure the fitness costs imposed by antibiotic resistance mutations. The fitness costs determined in the nematode were similar to those measured in mice, validating its use as a simple host model to evaluate bacterial fitness.

Place, publisher, year, edition, pages
2007. Vol. 51, no 2, 766-769 p.
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Medical and Health Sciences
URN: urn:nbn:se:uu:diva-146267DOI: 10.1128/AAC.00615-06ISI: 000243900600054PubMedID: 17116682OAI: oai:DiVA.org:uu-146267DiVA: diva2:397913
Available from: 2011-02-16 Created: 2011-02-16 Last updated: 2011-06-30Bibliographically approved

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Andersson, Dan I.
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