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Immunolocalization of prestin in human Cochlea
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Otolaryngology and Head and Neck Surgery.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Otolaryngology and Head and Neck Surgery.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Otolaryngology and Head and Neck Surgery.
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2010 (English)In: Audiological Medicine, ISSN 1651-386X, E-ISSN 1651-3835, Vol. 8, no 2, 56-62 p.Article in journal (Refereed) Published
Abstract [en]

 

 

 

 

 

 

Objective:

 

Prestin is an anion-transporter-related protein highly expressed in mammalian outer hair cells (OHCs). It is associated

with the OHC basolateral plasma membrane and responsible for cell body contraction, increasing cochlear sensitivity

and frequency resolution. Here, we analysed the expression and distribution of prestin in the human cochlea.

 

Study Design:

Immunohistochemistry including confocal microscopy and SEM were performed on EDTA-decalcifi ed human cochlea

removed during petro-clival meningioma surgery.

 

Results:

Prestin was found to be expressed solely in OHCs. No staining

was seen in IHCs. Prestin immunolabelling framed the OHCs along the sensory region of the human cochlea. Staining was

most prominent in the lateral cell membrane with less expression in the sub- and peri-nuclear part of the cell. Prestin immunostaining

was also detected in the OHC cytosol, presumably refl ecting intracellular molecular traffi cking.

 

Conclusion:

This

study describes for the fi rst time the localization and distribution of prestin in the well preserved human organ of Corti.

Place, publisher, year, edition, pages
2010. Vol. 8, no 2, 56-62 p.
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-146302DOI: 10.3109/16513860903320300OAI: oai:DiVA.org:uu-146302DiVA: diva2:397958
Available from: 2011-02-16 Created: 2011-02-16 Last updated: 2017-12-11Bibliographically approved

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Rask-Andersen, HelgeLiu, WeiBoström, Marja

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