Beta- and gamma-di- and tripeptides as potential substrates for the oligopeptide transporter hPepT1
2007 (English)In: Journal of Medicinal Chemistry, ISSN 0022-2623, E-ISSN 1520-4804, Vol. 50, no 21, 5238-5242 p.Article in journal (Refereed) Published
The hPepT1-mediated transport properties of a series of 11 synthesized beta- and gamma-peptides have been studied in Caco-2 cells. The results show that several of the compounds interact with the peptide transporter, but only two beta-dipeptides act as substrates and are transported across the cell monolayers. These two are less-efficient substrates than alfa-peptides. Larger derivatives than beta-dipeptides do not act as hPepT1 substrates, but instead, they appear to be substrates for P-glycoprotein efflux.
Place, publisher, year, edition, pages
2007. Vol. 50, no 21, 5238-5242 p.
IdentifiersURN: urn:nbn:se:uu:diva-12028DOI: 10.1021/jm070148uISI: 000250110700021PubMedID: 17887660OAI: oai:DiVA.org:uu-12028DiVA: diva2:39797