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Beta- and gamma-di- and tripeptides as potential substrates for the oligopeptide transporter hPepT1
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmacy.
Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Biochemistry and Organic Chemistry.
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2007 (English)In: Journal of Medicinal Chemistry, ISSN 0022-2623, E-ISSN 1520-4804, Vol. 50, no 21, 5238-5242 p.Article in journal (Refereed) Published
Abstract [en]

The hPepT1-mediated transport properties of a series of 11 synthesized beta- and gamma-peptides have been studied in Caco-2 cells. The results show that several of the compounds interact with the peptide transporter, but only two beta-dipeptides act as substrates and are transported across the cell monolayers. These two are less-efficient substrates than alfa-peptides. Larger derivatives than beta-dipeptides do not act as hPepT1 substrates, but instead, they appear to be substrates for P-glycoprotein efflux.

Place, publisher, year, edition, pages
2007. Vol. 50, no 21, 5238-5242 p.
National Category
Pharmaceutical Sciences
URN: urn:nbn:se:uu:diva-12028DOI: 10.1021/jm070148uISI: 000250110700021PubMedID: 17887660OAI: oai:DiVA.org:uu-12028DiVA: diva2:39797
Available from: 2007-11-19 Created: 2007-11-19 Last updated: 2011-01-20Bibliographically approved

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Hubatsch, InaArtursson, Per
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Department of PharmacyDepartment of Biochemistry and Organic Chemistry
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