uu.seUppsala University Publications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Localization of Progenitor/Stem Cells in the Human Tympanic Membrane
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Centre for Clinical Research, County of Västmanland.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Centre for Clinical Research, County of Västmanland.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Otolaryngology and Head and Neck Surgery.
2011 (English)In: Audiology & neuro-otology, ISSN 1420-3030, E-ISSN 1421-9700, Vol. 16, no 4, 263-269 p.Article in journal (Refereed) Published
Abstract [en]

Background: The outer epithelium of the tympanic membrane (TM) initiates the closure of a perforation. Embryonic stem cells have been used in attempts to enhance the healing capacity of induced perforations in experimental animals. More knowledge about epithelial cell proliferation and cell migration is needed for a better understanding of the TM healing process. This includes the identification of regenerative zones within the outer epithelial layer of the TM where progenitor cells may be present. Methods: Normal human TMs from translabyrinthine surgery were investigated using immunohistochemistry and immunofluorescence to detect the progenitor/stem cell markers α(6)-integrin, β(1)-integrin and cytokeratin 19 (CK19). Results: α(6)-Integrin was detected in the basal layer of the keratinizing epithelium in the umbo, in the annular region and along the malleus but not in the intermediate portion of the pars tensa. β(1)-Integrin and CK19 were found in the same locations not only in the basal layer but also in the suprabasal layers of the keratinizing epithelium. Conclusions: Possible progenitor cells are found in the umbo, the annular region and along the malleus. Further studies are needed to identify the source of these cells.

Place, publisher, year, edition, pages
2011. Vol. 16, no 4, 263-269 p.
Keyword [en]
Tympanic membrane, Progenitor cell, Stem cell, β1-integrin, α6-Integrin, Cytokeratin 19
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-146311DOI: 10.1159/000320612PubMedID: 21051884OAI: oai:DiVA.org:uu-146311DiVA: diva2:397974
Available from: 2011-02-16 Created: 2011-02-16 Last updated: 2017-12-11Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Authority records BETA

Knutsson, JohanRask-Andersen, Helge

Search in DiVA

By author/editor
Knutsson, JohanRask-Andersen, Helge
By organisation
Centre for Clinical Research, County of VästmanlandOtolaryngology and Head and Neck Surgery
In the same journal
Audiology & neuro-otology
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 373 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf