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Poorly soluble marketed drugs display solvation limited solubility
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmacy.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmacy.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmacy.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmacy.
2007 (English)In: Journal of Medicinal Chemistry, ISSN 0022-2623, E-ISSN 1520-4804, Vol. 50, no 23, p. 5858-5862Article in journal (Refereed) Published
Abstract [en]

We determined the intrinsic aqueous solubility of 15 poorly soluble drugs with solubilities ranging from 2.9 nM to 1.1 μM. We then analyzed the data from a physicochemical perspective, using experimentally determined solid-state properties and easily interpretable two-dimensional molecular descriptors, to better understand the factors underlying poor solubility. The analysis shows that poorly soluble drugs that have reached the market are solubility limited by solvation rather than by their solid state.

Place, publisher, year, edition, pages
2007. Vol. 50, no 23, p. 5858-5862
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Pharmaceutical Sciences
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URN: urn:nbn:se:uu:diva-12035DOI: 10.1021/jm0706416ISI: 000250809300040PubMedID: 17929794OAI: oai:DiVA.org:uu-12035DiVA, id: diva2:39804
Available from: 2007-11-19 Created: 2007-11-19 Last updated: 2018-01-12Bibliographically approved

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Bergström, ChristelHubatsch, Ina

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