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Acute psychotic symptoms in HIV-1 infected patients are associated with increased levels of kynurenic acid in cerebrospinal fluid
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm , Centre for Clinical Research, County of Västmanland.
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2007 (English)In: Brain, behavior, and immunity, ISSN 0889-1591, E-ISSN 1090-2139, Vol. 21, no 1, 86-91 p.Article in journal (Refereed) Published
Abstract [en]

Human immunodeficiency virus type 1 (HIV-1) infection is associated with psychiatric complications including cognitive impairment, affective disorders, and psychosis. Previous studies have revealed a disturbed kynurenine metabolism in these patients leading to increased levels of neuroactive compounds acting at glutamatergic neurotransmission. Kynurenic acid (KYNA), one of these metabolites is a glutamate-receptor antagonist, preferentially blocking the glycine site of the N-methyl-D-aspartate (NNIDA) receptor. Increased levels of brain KYNA have been suggested to induce a NNIDA receptor hypofunction that is associated with psychotic symptoms. In the present study, we analyze the concentration of KYNA in the cerebrospinal fluid (CSF) from HIV-1 infected patients (n = 22), including HIV-1 infected patients with psychotic symptoms (n = 8) and HIV-1 infected patients without psychiatric symptoms (n = 14). We found that HIV-1 infected patients had significantly higher median concentration of CSF KYNA (3.02 nM) compared to healthy controls (1.17 nM). Furthermore, CSF KYNA levels were significantly elevated in HIV-1 infected patients with psychotic symptoms (4.54 nM) compared to patients with HIV-1 without psychiatric symptoms (2.28 nNI). Present results indicate that increased levels of CSF KYNA may be associated with development of psychotic symptoms in HIV-1 infected patients.

Place, publisher, year, edition, pages
2007. Vol. 21, no 1, 86-91 p.
Keyword [en]
kynurenic acid, cerebrospinal fluid, HIV-1 infection, psychos, schizophrenia
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Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-146503DOI: 10.1016/j.bbi.2006.02.005ISI: 000243541300011PubMedID: 16603336OAI: oai:DiVA.org:uu-146503DiVA: diva2:398259
Available from: 2011-02-17 Created: 2011-02-17 Last updated: 2011-02-17Bibliographically approved

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