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Bistable bacterial growth rate in response to antibiotics with low membrane permeability
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology.
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology.
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology.
2006 (English)In: Physical Review Letters, ISSN 0031-9007, E-ISSN 1079-7114, Vol. 97, no 25, 258104- p.Article in journal (Refereed) Published
Abstract [en]

We demonstrate that growth rate bistability for bacterial cells growing exponentially at a fixed external antibiotic concentration can emerge when the cell wall permeability for the drug is low and the growth rate sensitivity to the intracellular drug concentration is high. Under such conditions, an initially high growth rate can remain high, due to dilution of the intracellular drug concentration by rapid cell volume increase, while an initially low growth rate can remain low, due to slow cell volume increase and insignificant drug dilution. Our findings have implications for the testing of novel antibiotics on growing bacterial strains.

Place, publisher, year, edition, pages
2006. Vol. 97, no 25, 258104- p.
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Biological Sciences
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URN: urn:nbn:se:uu:diva-146499DOI: 10.1103/PhysRevLett.94.258104ISI: 000243414600070PubMedID: 17280399OAI: oai:DiVA.org:uu-146499DiVA: diva2:398263
Available from: 2011-02-17 Created: 2011-02-17 Last updated: 2017-12-11Bibliographically approved

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Elf, Johan

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