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Rapid activation of haemostasis after hormonal emergency contraception
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical Chemistry.
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2007 (English)In: Thrombosis and Haemostasis, ISSN 0340-6245, Vol. 97, no 1, 15-20 p.Article in journal (Refereed) Published
Abstract [en]

Hormonal emergency contraception (EC) is a well established contraceptive method, recommended to all women, although the effects on haemostais are not fully evaluated. The aim of this study was to evaluate whether exposure to EC has effects on well established cardiovascular risk factors, and also to examine whether differences exist between two EC treatments. In a prospective randomized cross over design II women used two different EC methods, one with estrogen and levonorgestrel (EE-EC) and one with levonorgestrel only (LNG-EC). Plasma concentrations of haemostatic factors (APC resistance, antithrombin, fibrinogen, prothrombin fragment 1+2, free protein S, factor VII and PAI-I), sex-hormone-binding globulin (SHBG),the apolipoprotein (apo)B/apoAI ratio and C-reactive protein (CRP) were followed frequently during the following 48 hours.

Place, publisher, year, edition, pages
2007. Vol. 97, no 1, 15-20 p.
Keyword [en]
APC resistance, estrogen, levonorgestrel, SHBG
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-146493DOI: 10.1160/TH06-09-0540ISI: 000243432100006PubMedID: 17200765OAI: oai:DiVA.org:uu-146493DiVA: diva2:398271
Available from: 2011-02-17 Created: 2011-02-17 Last updated: 2011-02-17Bibliographically approved

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