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A 3-month preclinical trial to assess the performance of a new TVT-like mesh (TVTx) in a sheep model
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Obstetrics and Gynaecology. (Klinisk och experimentell reproduktionsbiologi/Olovsson)
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2007 (English)In: International Urogynecology Journal, ISSN 0937-3462, E-ISSN 1433-3023, Vol. 18, no 2, 183-187 p.Article in journal (Refereed) Published
Abstract [en]

The objective of this study was to evaluate in a sheep model the performance of a new polypropylene mesh (TVTx), which is intended as a less invasive treatment for female stress urinary incontinence. Eight female sheep were used in this study, each one being implanted with eight TVTx samples. At each time-point (weeks 1, 2, 4, and 12) seven TVTx were pulled out, while one TVTx was carefully dissected for histological investigations. One TVTx and one TVT, moreover, were inserted and immediately pulled out for obtaining the initial pullout forces in all sheep. The initial pullout values of TVT and TVTx were overlapping. The pullout forces of TVTx were > 5 N (500 g) and increasing from weeks 1 to 12 (p < 0.001). Histology revealed good tissue integration of TVTx in the tissue within 12 weeks after implantation. No abnormal histological findings were observed. This data could support the realization of a clinical trial with the TVTx mesh.

Place, publisher, year, edition, pages
2007. Vol. 18, no 2, 183-187 p.
Keyword [en]
stress urinary incontinence, tension-free vaginal tape, TVT, sheep model
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-146657DOI: 10.1007/s00192-006-0130-xISI: 000243189500010PubMedID: 16628374OAI: oai:DiVA.org:uu-146657DiVA: diva2:398688
Available from: 2011-02-18 Created: 2011-02-18 Last updated: 2015-09-15Bibliographically approved

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Rezapour, Masoumeh
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