uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Pediatric Organ Transplantation and Risk of Premalignant and Malignant Tumors in Sweden
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Rheumatology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Infectious Diseases.
Show others and affiliations
2011 (English)In: American Journal of Transplantation, ISSN 1600-6135, E-ISSN 1600-6143, Vol. 11, no 1, 146-151 p.Article in journal (Refereed) Published
Abstract [en]

Increased cancer risks are well documented in adult organ transplant recipients. However, the spectrum of malignancies and risk in the pediatric organ transplant population are less well described. We identified all solid organ transplanted patients aged < 18 in Sweden between 1970-2007 (n = 536) in the National Patient Register and linked to the Cancer Register. Nationwide rates were used to calculate standardized incidence rate ratios and 95% CI estimating the association between transplant and cancer during maximum 36 years of follow-up. Nearly 7% of pediatric solid organ transplant recipients developed a premalignant or malignant tumor during follow-up. Transplantation was associated with an increased risk of any cancer (n = 24, SIR = 12.5, 95% CI: 8.0-18.6): non-Hodgkin lymphoma (NHL) (n = 13, SIR = 127, 95% CI: 68-217), renal cell (n = 3, SIR = 105, 95% CI: 22-307), vulva/vagina (n = 3, SIR = 665, 95% CI: 137-1934) and nonmelanoma skin cancers (n = 2, SIR = 64.7, 95% CI: 7.8-233.8). NHL typically appeared during childhood, while other tumors were diagnosed during adulthood. Apart from short-term attention toward the potential occurrence of NHL, our results suggest cancer surveillance into adulthood with special attention to skin, kidneys and the female genitalia.

Place, publisher, year, edition, pages
2011. Vol. 11, no 1, 146-151 p.
Keyword [en]
Cancer, malignancy, pediatric solid organ transplantation, pediatric transplant
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-146892DOI: 10.1111/j.1600-6143.2010.03367.xISI: 000285783500021PubMedID: 21199354OAI: oai:DiVA.org:uu-146892DiVA: diva2:399226
Available from: 2011-02-21 Created: 2011-02-21 Last updated: 2014-08-13Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Baecklund, EvaKinch, AmelieMolin, Daniel
By organisation
RheumatologyInfectious DiseasesOncology
In the same journal
American Journal of Transplantation
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 160 hits
ReferencesLink to record
Permanent link

Direct link