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Secretogranin III in human neuroendocrine tumours A comparative immunohistochemical study with chromogranins A and B and secretogranin II
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Genetics and Pathology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical Chemistry.
2010 (English)In: Regulatory Peptides, ISSN 0167-0115, E-ISSN 1873-1686, Vol. 165, no 1, 30-35 p.Article in journal (Refereed) Published
Abstract [en]

Background: Different epitopes of the granin family of proteins, chromogranin (Cg) A, CgB and secretogranin (Sg) II, have been demonstrated in normal human pancreas, gastrointestinal tract, adrenal medulla and in several neuroendocrine tumours (NETs). SgIII has been recently reported in endocrine pancreas. The aim of the present study was to examine the expression of SgIII in different NETs and compare it with the expression of CgA. CgB and SgII epitopes. Material and methods: Tissue specimens from 47 NETs were analyzed. Antibodies to CgA 250-284, CgB 244-255. SgII 172-186 (C-terminal secretoneurin) and SgIII 348-361 were used for immunostaining. Results: SgIII was expressed in 41 of 47 NETs. The expression of SgIII agreed well with that of CgA, CgB and SgII, with exceptions of phaeochromocytomas, where more CgB and SgII immunoreactive cells were observed and parathyroid adenomas, which were only stained by CgA. In rectal NETs more cells expressed SgIII than CgA. Conclusions: This is the first report on SgIII expression in various NETs. A majority of tumours studied displayed SgIII immunostaining, which indicates a functional relationship with the other granins.

Place, publisher, year, edition, pages
2010. Vol. 165, no 1, 30-35 p.
Keyword [en]
Neuroendocrine tumours, Secretogranin III, Chromogranin A, Chromogranin B, Secretogranin II, Granins, Immunohistochemistry
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-146876DOI: 10.1016/j.regpep.2010.06.002ISI: 000286155900006PubMedID: 20550951OAI: oai:DiVA.org:uu-146876DiVA: diva2:399286
Available from: 2011-02-21 Created: 2011-02-21 Last updated: 2011-02-21Bibliographically approved

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