The contact system - a novel branch of innate immunity generating antibacterial peptides
2006 (English)In: EMBO Journal, ISSN 0261-4189, E-ISSN 1460-2075, Vol. 25, no 23, 5569-5578 p.Article in journal (Refereed) Published
Activation of the contact system has two classical consequences: initiation of the intrinsic pathway of coagulation, and cleavage of high molecular weight kininogen (HK) leading to the release of bradykinin, a potent proinflammatory peptide. In human plasma, activation of the contact system at the surface of significant bacterial pathogens was found to result in further HK processing and bacterial killing. A fragment comprising the D3 domain of HK is generated, and within this fragment a sequence of 26 amino acids is mainly responsible for the antibacterial activity. A synthetic peptide covering this sequence kills several bacterial species, also at physiological salt concentration, as effectively as the classical human antibacterial peptide LL-37. Moreover, in an animal model of infection, inhibition of the contact system promotes bacterial dissemination and growth. These data identify a novel and important role for the contact system in the defence against invasive bacterial infection.
Place, publisher, year, edition, pages
2006. Vol. 25, no 23, 5569-5578 p.
antibacterial peptides, bacterial killing, contact system, innate immunity
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:uu:diva-146981DOI: 10.1038/sj.emboj.7601422ISI: 000242890900012PubMedID: 17093496OAI: oai:DiVA.org:uu-146981DiVA: diva2:399516