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Single molecule approaches to transcription factor kinetics in living cells
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology.
2009 (English)In: FEBS Letters, ISSN 0014-5793, E-ISSN 1873-3468, Vol. 583, no 24, 3979-3983 p.Article in journal (Refereed) Published
Abstract [en]

Quantitative modeling of intracellular processes often requires information about intracellular rate constants as well as the concentrations of low abundance species in individual cells. Single molecule imaging techniques offer not only new ways for obtaining such information but also the possibilities to test model-based hypotheses that have previously been out of reach for experiments. In this review we highlight some advantages of single molecule techniques and exemplify by their capability to help understanding how transcription factors find their chromosomal binding sites in bacterial cells.

Place, publisher, year, edition, pages
2009. Vol. 583, no 24, 3979-3983 p.
Keyword [en]
Single molecule, Transcription factor, Facilitated diffusion
National Category
Biological Sciences
URN: urn:nbn:se:uu:diva-137685DOI: 10.1016/j.febslet.2009.11.035ISI: 000273208000015OAI: oai:DiVA.org:uu-137685DiVA: diva2:399575
Available from: 2011-02-22 Created: 2010-12-15 Last updated: 2016-04-21Bibliographically approved

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Elf, Johan
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