uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Differential CSF biomarker levels in APOE-epsilon 4-positive and -negative patients with memory impairment
Show others and affiliations
2007 (English)In: Dementia and Geriatric Cognitive Disorders, ISSN 1420-8008, E-ISSN 1421-9824, Vol. 23, no 2, 87-95 p.Article in journal (Refereed) Published
Abstract [en]

Objectives: To investigate the relationships between episodic memory, APOE genotype, CSF markers (total tau, T-tau; phospho-tau, P-tau; beta-amyloid, A beta 42) and longitudinal cognitive decline. Methods: 124 memory clinic patients were retrospectively divided into 6 groups based on (i) episodic memory function (Rey Auditory Verbal Learning Test, RAVLT): severe, moderate or no impairment (SIM, MIM or NIM), and (ii) APOE genotype (epsilon 4+ or epsilon 4-). CSF marker levels and cognitive decline were compared across groups. Results: Episodic memory function, according to RAVLT scores, was significantly correlated with CSF marker levels only among epsilon 4+ subjects and not among epsilon 4- subjects. When comparing the 6 subgroups, SIM epsilon 4+ and MIM epsilon 4+ groups showed significantly lower A beta 42 levels than the other groups. T-tau and P- tau levels were significantly increased in SIM epsilon 4+ when compared to all the other groups, including the SIM epsilon 4- group. However, both SIM epsilon 4+ and SIM epsilon 4- declined cognitively during the follow-up. Conclusion: It remains to be determined whether APOE genotype affects the expression of biomarkers in CSF, or whether the different biomarker patterns reflect different types of disease processes in patients with progressive cognitive dysfunction.

Place, publisher, year, edition, pages
2007. Vol. 23, no 2, 87-95 p.
Keyword [en]
episodic memory, cognitive decline, CSF biomarkers, apolipoprotein E genotype
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-146994DOI: 10.1159/000097354ISI: 000242847400004PubMedID: 17124416OAI: oai:DiVA.org:uu-146994DiVA: diva2:399608
Available from: 2011-02-23 Created: 2011-02-23 Last updated: 2011-02-23Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed
By organisation
In the same journal
Dementia and Geriatric Cognitive Disorders
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 153 hits
ReferencesLink to record
Permanent link

Direct link