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Genetic architecture of metabolic rate: environment specific epistasis between mitochondrial and nuclear genes in an insect
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Ecology and Evolution, Animal Ecology.
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2010 (English)In: Evolution, ISSN 0014-3820, E-ISSN 1558-5646, Vol. 64, no 12, 3354-3363 p.Article in journal (Refereed) Published
Abstract [en]

The extent to which mitochondrial DNA (mtDNA) variation is involved in adaptive evolutionary change is currently being reevaluated. In particular, emerging evidence suggests that mtDNA genes coevolve with the nuclear genes with which they interact to form the energy producing enzyme complexes in the mitochondria. This suggests that intergenomic epistasis between mitochondrial and nuclear genes may affect whole-organism metabolic phenotypes. Here, we use crossed combinations of mitochondrial and nuclear lineages of the seed beetle Callosobruchus maculatus and assay metabolic rate under two different temperature regimes. Metabolic rate was affected by an interaction between the mitochondrial and nuclear lineages and the temperature regime. Sequence data suggests that mitochondrial genetic variation has a role in determining the outcome of this interaction. Our genetic dissection of metabolic rate reveals a high level of complexity, encompassing genetic interactions over two genomes, and genotype x genotype x environment interactions. The evolutionary implications of these results are twofold. First, because metabolic rate is at the root of life histories, our results provide insights into the complexity of life-history evolution in general, and thermal adaptation in particular. Second, our results suggest a mechanism that could contribute to the maintenance of nonneutral mtDNA polymorphism.

Place, publisher, year, edition, pages
2010. Vol. 64, no 12, 3354-3363 p.
Keyword [en]
Epistasis, life-history evolution, metabolism, mtDNA, polymorphism, thermal adaptation
National Category
Biological Sciences
Identifiers
URN: urn:nbn:se:uu:diva-147102DOI: 10.1111/j.1558-5646.2010.01135.xISI: 000284850100003PubMedID: 20874734OAI: oai:DiVA.org:uu-147102DiVA: diva2:399955
Available from: 2011-02-24 Created: 2011-02-24 Last updated: 2017-12-11Bibliographically approved

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Arnqvist, Göran

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