uu.seUppsala University Publications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
The ribosome-bound Hsp70 homolog Ssb of Saccharomyces cerevisiae
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology, Molecular Biology.
2010 (English)In: Biochimica et Biophysica Acta. Molecular Cell Research, ISSN 0167-4889, E-ISSN 1879-2596, Vol. 1803, no 6, 662-672 p.Article, review/survey (Refereed) Published
Abstract [en]

The Hsp70 homolog Ssb directly binds to the ribosome and contacts a variety of newly synthesized polypeptide chains as soon as they emerge from the ribosomal exit tunnel For this reason a general role of Ssb in the de novo folding of newly synthesized proteins is highly suggestive. However, for more than a decade client proteins which require Ssb for proper folding have remained elusive. It was therefore speculated that Ssb, despite its ability to Interact with a large variety of nascent polypeptides, may assist the folding of only a small and specific subset. Alternatively, It has been suggested that Ssb's function may be limited to the protection of nascent polypeptides from aggregation until downstream chaperones take over and actively fold their substrates. There is also evidence that Ssb, in parallel to a classical chaperone function, is involved in the regulation of cellular signaling processes. Here we aim to summarize what is currently known about Ssb's multiple functions and what remains to be ascertained by future research.

Place, publisher, year, edition, pages
2010. Vol. 1803, no 6, 662-672 p.
Keyword [en]
Chaperones, Hsp70, Ribosome, Protein folding, SNF1, Signaling, Translation, Translational fidelity, Saccharomyces cerevisiae
National Category
Biological Sciences
Identifiers
URN: urn:nbn:se:uu:diva-147148DOI: 10.1016/j.bbamcr.2010.03.005ISI: 000278638900004OAI: oai:DiVA.org:uu-147148DiVA: diva2:399970
Available from: 2011-02-24 Created: 2011-02-24 Last updated: 2017-12-11Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full text
By organisation
Molecular Biology
In the same journal
Biochimica et Biophysica Acta. Molecular Cell Research
Biological Sciences

Search outside of DiVA

GoogleGoogle Scholar

doi
urn-nbn

Altmetric score

doi
urn-nbn
Total: 417 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf