uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
The ribosome-bound Hsp70 homolog Ssb of Saccharomyces cerevisiae
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology, Molecular Biology.
2010 (English)In: Biochimica et Biophysica Acta. Molecular Cell Research, ISSN 0167-4889, Vol. 1803, no 6, 662-672 p.Article, review/survey (Refereed) Published
Abstract [en]

The Hsp70 homolog Ssb directly binds to the ribosome and contacts a variety of newly synthesized polypeptide chains as soon as they emerge from the ribosomal exit tunnel For this reason a general role of Ssb in the de novo folding of newly synthesized proteins is highly suggestive. However, for more than a decade client proteins which require Ssb for proper folding have remained elusive. It was therefore speculated that Ssb, despite its ability to Interact with a large variety of nascent polypeptides, may assist the folding of only a small and specific subset. Alternatively, It has been suggested that Ssb's function may be limited to the protection of nascent polypeptides from aggregation until downstream chaperones take over and actively fold their substrates. There is also evidence that Ssb, in parallel to a classical chaperone function, is involved in the regulation of cellular signaling processes. Here we aim to summarize what is currently known about Ssb's multiple functions and what remains to be ascertained by future research.

Place, publisher, year, edition, pages
2010. Vol. 1803, no 6, 662-672 p.
Keyword [en]
Chaperones, Hsp70, Ribosome, Protein folding, SNF1, Signaling, Translation, Translational fidelity, Saccharomyces cerevisiae
National Category
Biological Sciences
URN: urn:nbn:se:uu:diva-147148DOI: 10.1016/j.bbamcr.2010.03.005ISI: 000278638900004OAI: oai:DiVA.org:uu-147148DiVA: diva2:399970
Available from: 2011-02-24 Created: 2011-02-24 Last updated: 2011-02-24Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full text
By organisation
Molecular Biology
In the same journal
Biochimica et Biophysica Acta. Molecular Cell Research
Biological Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 198 hits
ReferencesLink to record
Permanent link

Direct link