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Effects of Congo Red on A beta(1-40) Fibril Formation Process and Morphology
Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Biochemistry and Organic Chemistry.
Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy.
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2010 (English)In: ACS CHEMICAL NEUROSCIENCE, ISSN 1948-7193, Vol. 1, no 4, 315-324 p.Article in journal (Refereed) Published
Abstract [en]

Alzheimer's disease (AD), an age-related neurodegenerative disorder, is the most common form of dementia, and the seventh-leading cause of death in the United States. Current treatments offer only symptomatic relief; thus, there is a great need for new treatments with disease-modifying potential. One pathological hallmark of AD is so-called senile plaques, mainly made up of beta-sheet-rich assemblies of 40- or 42-residue amyloid beta-peptides (A beta). Hence, inhibition of A beta aggregation is actively explored as an option to prevent or treat AD. Congo red (CR) has been widely used as a model antiamyloid agent to prevent A beta aggregation. Herein, we report detailed morphological studies on the effect of CR as an antiamyloid agent, by circular dichroism spectroscopy, photo-induced cross-linking reactions, and atomic force microscopy. We also demonstrate the effect of CR on a preaggregated sample of A beta(1-40). Our result suggests that A beta(1-40) follows a different path for aggregation in the presence of CR.

Place, publisher, year, edition, pages
2010. Vol. 1, no 4, 315-324 p.
Keyword [en]
Alzheimer's disease, atomic force microscopy, Congo red, amyloid, oligomers, fibrils, aggregates, amyloid beta-peptide
National Category
Chemical Sciences
Identifiers
URN: urn:nbn:se:uu:diva-147231DOI: 10.1021/cn900041xISI: 000277981200008OAI: oai:DiVA.org:uu-147231DiVA: diva2:400101
Available from: 2011-02-24 Created: 2011-02-24 Last updated: 2011-02-24Bibliographically approved

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Department of Biochemistry and Organic ChemistryDepartment of Physics and AstronomySurface and Interface Science
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