Effects of Congo Red on A beta(1-40) Fibril Formation Process and Morphology
2010 (English)In: ACS CHEMICAL NEUROSCIENCE, ISSN 1948-7193, Vol. 1, no 4, 315-324 p.Article in journal (Refereed) Published
Alzheimer's disease (AD), an age-related neurodegenerative disorder, is the most common form of dementia, and the seventh-leading cause of death in the United States. Current treatments offer only symptomatic relief; thus, there is a great need for new treatments with disease-modifying potential. One pathological hallmark of AD is so-called senile plaques, mainly made up of beta-sheet-rich assemblies of 40- or 42-residue amyloid beta-peptides (A beta). Hence, inhibition of A beta aggregation is actively explored as an option to prevent or treat AD. Congo red (CR) has been widely used as a model antiamyloid agent to prevent A beta aggregation. Herein, we report detailed morphological studies on the effect of CR as an antiamyloid agent, by circular dichroism spectroscopy, photo-induced cross-linking reactions, and atomic force microscopy. We also demonstrate the effect of CR on a preaggregated sample of A beta(1-40). Our result suggests that A beta(1-40) follows a different path for aggregation in the presence of CR.
Place, publisher, year, edition, pages
2010. Vol. 1, no 4, 315-324 p.
Alzheimer's disease, atomic force microscopy, Congo red, amyloid, oligomers, fibrils, aggregates, amyloid beta-peptide
IdentifiersURN: urn:nbn:se:uu:diva-147231DOI: 10.1021/cn900041xISI: 000277981200008OAI: oai:DiVA.org:uu-147231DiVA: diva2:400101