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Long-term (5-year) antibody persistence following two- and three-dose regimens of a combined hepatitis A and B vaccine in children aged 1-11 years
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm , Centrum för klinisk forskning i D län (CKFD).
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2010 (English)In: Vaccine, ISSN 0264-410X, E-ISSN 1873-2518, Vol. 28, no 27, 4411-4415 p.Article in journal (Refereed) Published
Abstract [en]

This study compared the long-term persistence of anti-hepatitis A (anti-HAV) and B (anti-HBs) antibodies, 5 years after vaccination of subjects aged 1-11 years with a combined hepatitis A and B vaccine either in a two-dose (0, 6 months, Adult formulation) or a three-dose (0, 1, 6 months, Paediatric formulation) schedule. At the end of the 5 years, all subjects (100%) in both groups continued to have anti-HAV antibodies >= 15 mIU/mL, while 94-97% of subjects in both groups had anti-HBs antibody concentrations >= 10 mIU/mL Subjects with anti-HBs antibody concentration <= 10 mIU/mL were administered a challenge dose of hepatitis B vaccine. All subjects mounted a vigorous immune response to the challenge indicating the presence of immunological memory to HBV.

Place, publisher, year, edition, pages
2010. Vol. 28, no 27, 4411-4415 p.
Keyword [en]
Hepatitis, Paediatric, Combined
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-147211DOI: 10.1016/j.vaccine.2010.04.040ISI: 000279153400011OAI: oai:DiVA.org:uu-147211DiVA: diva2:400164
Available from: 2011-02-24 Created: 2011-02-24 Last updated: 2011-02-24Bibliographically approved

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