uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
The cutaneous non-neuronal cholinergic system and smoking related dermatoses: Studies of the psoriasis variant palmoplantar pustulosis
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Dermatology and Venereology.
2007 (English)In: Life Sciences, ISSN 0024-3205, E-ISSN 1879-0631, Vol. 80, no 24-25, 2227-2234 p.Article in journal (Refereed) Published
Abstract [en]

Palmoplantar pustulosis (PPP) is probably the inflammatory skin disease most strongly associated to smoking. The disease is common in middle-aged, smoking women, and is chronic, sometimes disabling and characterized by pustules, erythema and scaling on the soles and palms. It is often treatment-resistant. PPP patients have a co-morbidity with an increased risk of autoimmune thyroid disease, celiac disease/gluten intolerance, abnormal calcium homeostasis, diabetes type 2, and depression. The sweat gland apparatus is involved in the pathogenesis of PPP since a) the normal structure of the acrosyringium is abolished so the keratin pattern differs to that in normal palmar skin; b) granulocytes migrate outwards in the acrosyringium forming the pustule in the stratum corneum. Acetylcholine (ACh) is the main inducer of sweating. With immunohistochemistry the ACh synthesizing enzyme choline acetyltransferase (ChAT) and the ACh-degrading enzyme acetylcholinesterase (AChE) were found to be strongly expressed in the gland and duct as were the alpha-3 and alpha-7 nicotinic acetylcholine receptors (nAChRs). Smoking influenced the staining intensity of the enzymes and the alpha-3 nAChR in healthy subjects. In involved PPP skin there was a massive infiltration of granulocytes expressing ChAT and alpha-3 nAChR, and mast cells expressing AChE indicating a role for acetylcholine in inflammation. Cessation of smoking resulted in fewer pustules, and less scaling and erythema. The mechanisms for the effect of nicotine/smoking in PPP are still unknown but nicotine may lead to enhanced inflammation in consideration of the properties of the sweat duct and/or nicotine might facilitate autoimmune reactions.

Place, publisher, year, edition, pages
2007. Vol. 80, no 24-25, 2227-2234 p.
Keyword [en]
Inflammation, Autoimmune, Systemic disease, Choline acetyltransferase, Acetylcholinesterase, α-3 and α-7 nicotinic receptors, Autoantibodies
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-12268DOI: 10.1016/j.lfs.2007.01.045ISI: 000247520900011OAI: oai:DiVA.org:uu-12268DiVA: diva2:40037
Available from: 2008-01-10 Created: 2008-01-10 Last updated: 2011-04-08Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full text

Search in DiVA

By author/editor
Hagforsen, Eva
By organisation
Dermatology and Venereology
In the same journal
Life Sciences
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 151 hits
ReferencesLink to record
Permanent link

Direct link