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Molecular Design and Optimization of 99mTc-Labeled Recombinant Affibody Molecules Improves Their Biodistribution and Imaging Properties
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Radiology, Oncology and Radiation Science, Biomedical Radiation Sciences. (Orlova)ORCID iD: 0000-0001-6120-2683
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Radiology, Oncology and Radiation Science, Biomedical Radiation Sciences. (Tolmachev)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Radiology, Oncology and Radiation Science, Biomedical Radiation Sciences. (Tolmachev)
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2011 (English)In: Journal of Nuclear Medicine, ISSN 0161-5505, E-ISSN 1535-5667, Vol. 52, no 3, 461-469 p.Article in journal (Refereed) Published
Abstract [en]

These results demonstrate that the biodistribution properties of recombinant (99m)Tc-labeled Affibody molecules can be optimized by modification of the C-terminal cysteine-containing chelating sequence. (99m)Tc-Z(HER2)(:V2) is a promising candidate for further development as a diagnostic radiopharmaceutical for imaging of HER2-expressing tumors. These results may be useful for the development of imaging agents based on other Affibody molecules and, hopefully, other scaffolds.

Place, publisher, year, edition, pages
2011. Vol. 52, no 3, 461-469 p.
Keyword [en]
Affibody molecule, Tc-99m, molecular imaging, HER2, C-terminal cysteine
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-147603DOI: 10.2967/jnumed.110.083592ISI: 000287578200029PubMedID: 21321280OAI: oai:DiVA.org:uu-147603DiVA: diva2:400564
Available from: 2011-02-26 Created: 2011-02-26 Last updated: 2017-12-11Bibliographically approved

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Orlova, Anna

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