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Characterization of the rnpB gene and the RNase P RNA in the order of Chlamydiales
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical Bacteriology.
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology.
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2000 (English)In: International Journal of Systematic and Evolutionary Microbiology, ISSN 1466-5026, E-ISSN 1466-5034, Vol. 50, no Part 1, 149-158 p.Article in journal (Refereed) Published
Abstract [en]

The sequence of the RNase P RNA gene (rnpB) was determined for 60 strains representing all nine species in the family Chlamydiaceae and for the related Chlamydiales species, Parachlamydia acanthamoebae and Simkania negevensis. These sequences were used to infer evolutionary relationships among the Chlamydiaceae. The analysis separated Chlamydophila and Chlamydia into two lineages, with Chlamydophila forming three distinct clusters: the Chlamydophila pneumoniae strains; the Chlamydophila pecorum strains; and a third cluster comprising the species Chlamydophila psittaci, Chlamydophila abortus, Chlamydophila caviae and Chlamydophila felis. The Chlamydia line of descent contained two clusters, with the Chlamydia suis strains distinctly separated from strains of Chlamydia trachomatis and Chlamydia muridarum. This analysis indicated that the rnpB sequence and structure are distinctive markers for species in the Chlamydiaceae. It was also demonstrated that the RNase P RNA derived from Chlamydia trachomatis is able to cleave a tRNA precursor in the absence of protein. These findings are discussed in relation to the structure of Chlamydia RNase P RNA.

Place, publisher, year, edition, pages
2000. Vol. 50, no Part 1, 149-158 p.
Keyword [en]
RNase P RNA, rnpB, phylogeny, Chlamydia, Simkania
National Category
Natural Sciences
URN: urn:nbn:se:uu:diva-147831ISI: 000085673600019PubMedID: 10826799OAI: oai:DiVA.org:uu-147831DiVA: diva2:400918
Available from: 2011-02-28 Created: 2011-02-28 Last updated: 2011-03-01Bibliographically approved

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Clinical BacteriologyDepartment of Cell and Molecular Biology
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