uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
RNase P: a 'Scarlet Pimpernel'
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology. (Kirsebom)
1995 (English)In: Molecular Microbiology, ISSN 0950-382X, E-ISSN 1365-2958, Vol. 17, no 3, 411-420 p.Article, review/survey (Refereed) Published
Abstract [en]

RNase P is responsible for the maturation of the 5'-termini of tRNA molecules in all cells studied to date. This ribonucleoprotein has to recognize and identify its cleavage site on a large number of different precursors. This review covers what is currently known about the function of the catalytic subunit of Escherichia coli RNase P, M1 RNA, and the protein subunit, C5, in particular with respect to cleavage-site selection. Recent genetic and biochemical data show that the two C residues in the 3'-terminal CCA sequence of a precursor interact with the enzyme through Watson-Crick base-pairing. This is suggested to result in unfolding of the amino acid acceptor-stem and exposure of the cleavage site. Furthermore, other close contact points between M1 RNA and its substrate have recently been identified. These data, together with the two existing three-dimensional structure models of M1 RNA in complex with its substrate, establish a platform that will enable us to seek an understanding of the underlying mechanism of cleavage by this elusive enzyme.

Place, publisher, year, edition, pages
1995. Vol. 17, no 3, 411-420 p.
National Category
Natural Sciences
URN: urn:nbn:se:uu:diva-147843DOI: 10.1111/j.1365-2958.1995.mmi_17030411.xPubMedID: 8559060OAI: oai:DiVA.org:uu-147843DiVA: diva2:400934
Available from: 2011-02-28 Created: 2011-02-28 Last updated: 2011-03-02Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed
By organisation
Department of Cell and Molecular Biology
In the same journal
Molecular Microbiology
Natural Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 124 hits
ReferencesLink to record
Permanent link

Direct link