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Roles of metal ions in RNase P catalysis
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology. (Kirsebom)
2010 (English)In: Ribonuclease P / [ed] Fenyong Liu & Sidney Altman, New York: Springer-Verlag New York, 2010, 113-134 p.Chapter in book (Other academic)
Abstract [en]

As for other RNA, RNase P with its catalytic RNA subunit requires metal(II)-ions for function. Approximately 100 metal(II)-ions bind to the 400 residues long RNA and several to the precursor substrate, e.g., roughly 25–30 to a tRNA precursor substrate. To understand the function and the reaction catalyzed by RNase P an important task is to identify and characterize metal(II)-ions or metal binding sites that contribute to folding of the RNAs, interaction with the protein subunit(s), substrate binding and chemistry of cleavage. Over the years, different methods have been explored to extract information about how, were and when metal(II)-ions bind to RNA. In this chapter, I will discuss our current understanding of RNase P and metal(II)-ions and how this knowledge can be utilized to search for new candidate drugs referred to as metal mimics.

Place, publisher, year, edition, pages
New York: Springer-Verlag New York, 2010. 113-134 p.
, Protein Reviews, 10
National Category
Natural Sciences
URN: urn:nbn:se:uu:diva-147849DOI: 10.1007/978-1-4419-1142-1_7ISBN: 978-1-4419-1142-1ISBN: 978-1-4419-1141-4OAI: oai:DiVA.org:uu-147849DiVA: diva2:400944
Available from: 2011-02-28 Created: 2011-02-28 Last updated: 2012-02-08Bibliographically approved

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