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Stress effects on AVT and CRF systems in two strains of rainbow trout (Oncorhynchus mykiss) divergent in stress responsiveness
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Organism Biology, Comparative Physiology. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Physiology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Physiology.
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2011 (English)In: Hormones and Behavior, ISSN 0018-506X, E-ISSN 1095-6867, Vol. 59, no 1, p. 180-186Article in journal (Refereed) Published
Abstract [en]

The aim for this study was to examine whether the F4 generation of two strains of rainbow trout divergent in their plasma cortisol response to confinement stress (HR: high responder or LR: low responder) would also differ in stress-induced effects on forebrain concentrations of mRNA for corticotropin-releasing factor (CRF). arginine vasotocin (AVT). CRF receptor type 1 (CRF-R1). CRF receptor type 2 (CRF-R2) and AVT receptor (AVT-R). In addition, plasma cortisol concentrations, brainstem levels of monoamines and monoamine metabolites, and behaviour during confinement were monitored. The results confirm that HR and LR trout differ in their cortisol response to confinement and show that fish of these strains also differ in their behavioural response to confinement. The HR trout displayed significantly higher locomotor activity while in confinement than LR trout. Moreover, following 180 min of confinement HR fish showed significantly higher forebrain concentrations of CRF mRNA than LR fish. Also, when subjected to 30 min of confinement HR fish showed significantly lower CRF-R2 mRNA concentrations than LR fish, whereas there were no differences in CRF-R1. AVT or AVT-R mRNA expression between LR and HR fish either at 30 or 180 min of confinement. Differences in the expression of CRF and CRF-R2 mRNA may be related to the divergence in stress coping displayed by these rainbow trout strains.

Place, publisher, year, edition, pages
2011. Vol. 59, no 1, p. 180-186
Keywords [en]
Arginine vasotocin (AVT), Confinement stress, Corticotropin-releasing factor (CRF), Cortisol, Hypothalamic-pituitary-interrenal (HPI) axis, Monoamines, Stress coping styles
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Biological Sciences
Identifiers
URN: urn:nbn:se:uu:diva-148129DOI: 10.1016/j.yhbeh.2010.11.008ISI: 000286717600024PubMedID: 21087609OAI: oai:DiVA.org:uu-148129DiVA, id: diva2:401465
Available from: 2011-03-02 Created: 2011-03-02 Last updated: 2017-12-11Bibliographically approved

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