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Genome Sequence, Comparative Analysis, and Population Genetics of the Domestic Horse
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology.
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2009 (English)In: Science, ISSN 0036-8075, E-ISSN 1095-9203, Vol. 326, no 5954, 865-867 p.Article in journal (Refereed) Published
Abstract [en]

We report a high-quality draft sequence of the genome of the horse ( Equus caballus). The genome is relatively repetitive but has little segmental duplication. Chromosomes appear to have undergone few historical rearrangements: 53% of equine chromosomes show conserved synteny to a single human chromosome. Equine chromosome 11 is shown to have an evolutionary new centromere devoid of centromeric satellite DNA, suggesting that centromeric function may arise before satellite repeat accumulation. Linkage disequilibrium, showing the influences of early domestication of large herds of female horses, is intermediate in length between dog and human, and there is long-range haplotype sharing among breeds.

Place, publisher, year, edition, pages
2009. Vol. 326, no 5954, 865-867 p.
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Biological Sciences
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URN: urn:nbn:se:uu:diva-148228DOI: 10.1126/science.1178158ISI: 000271468000047PubMedID: 19892987OAI: oai:DiVA.org:uu-148228DiVA: diva2:401574
Available from: 2011-03-03 Created: 2011-03-03 Last updated: 2017-12-11Bibliographically approved

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Andersson, LeifLindblad-Toh, Kerstin

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