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Study of the Interaction Between the Amyloid Beta Peptide (1-40) and Antioxidant Compounds by Nuclear Magnetic Resonance Spectroscopy
Department of Pharmacy, University of Patras, Panepistimioupoli, Greece.
Department of Pharmacy, University of Patras, Panepistimioupoli and GAIA Research Center, Bioanalytical Department, Greece. .
Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Physical and Analytical Chemistry, Analytical Chemistry.
Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Physical and Analytical Chemistry, Analytical Chemistry.
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2011 (English)In: Biopolymers, ISSN 0006-3525, E-ISSN 1097-0282, Vol. 96, no 3, 316-327 p.Article in journal (Refereed) Published
Abstract [en]

Amyloid beta peptide (Aβ) aggregation leads to the senile plaque formation, a process that is strongly influenced by oxidative stress and is considered as the molecular basis of various neurodegenerative diseases, such as Alzheimer's Disease (AD). Endogenous antioxidants or dietary derived compounds may down-regulate this process. In this study, the interaction of two antioxidants, oleuropein (OE) and melatonin (M) with Aβ, is monitored through NMR spectroscopy and Mass Spectrometry. The concerted application of these two analytical techniques provides new experimental evidence and residue-specific insights into the interacting Aβ peptide amino acids that are implicated in this process. Both antioxidant compounds interact in a similar way with the peptide and cause chemical shift variations. The most pronounced resonance changes have been observed for the (1)H-(15)N signals of N-terminal region and Leu(17)-Phe(20) residues, as monitored by NMR titration studies.

Place, publisher, year, edition, pages
2011. Vol. 96, no 3, 316-327 p.
Keyword [en]
NMR spectroscopy, amyloid-beta-peptide, oleuropein, melatonin
National Category
Chemical Sciences
Identifiers
URN: urn:nbn:se:uu:diva-148453DOI: 10.1002/bip.21558ISI: 000290458800008PubMedID: 21053258OAI: oai:DiVA.org:uu-148453DiVA: diva2:402176
Available from: 2011-03-07 Created: 2011-03-07 Last updated: 2017-12-11Bibliographically approved

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Bergquist, JonasMarkides, Karin

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