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Psychopathy, PCL-R, and MAOA genotype as predictors of violent reconvictions
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm , Centre for Clinical Research, County of Västmanland.
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2011 (English)In: Psychiatry Research, ISSN 0165-1781, E-ISSN 1872-7123, Vol. 185, no 3, 382-386 p.Article in journal (Refereed) Published
Abstract [en]

The Revised Psychopathy Checklist (PCL-R) has shown a moderate association with violence. The efficacy of PCL-R in varying monoamine oxidase A (MAOA) genotypes is, however, unexamined. The aim of this study was to investigate the effect of PCL-R and psychopathy on the risk for violent reconvictions among 167 MAOA genotyped alcoholic offenders. Violent reconvictions and PCL-R scores among violent offenders were assessed after a 7-year non-incarcerated follow-up. Regression analysis was used to evaluate the alcohol exposure and age-adjusted effect of PCL-R score and psychopathy on the risk for reconvictions among differing MAOA genotypes. Results suggest that the PCL-R total score predicts impulsive reconvictions among high-activity MAOA offenders (6.8% risk increase for every one-point increase in PCL-R total score. P=0.015), but not among low-activity MAOA offenders, whereas antisocial behavior and attitudes predicted reconvictions in both genotypes (17% risk increase among high-activity MAOA offenders and 12.8% increase among low-activity MAOA offenders for every one-point increase in factor 2 score). Both narcissistic self-image with related interpersonal style (factor 1 score) and psychopathy (PCL-R >= 30) failed to predict future violence. Results suggest that the efficacy of PCL-R is altered by MAOA genotype, alcohol exposure, and age, which seems important to note when PCL-R is used for risk assessments that will have legal or costly preventive work consequences.

Place, publisher, year, edition, pages
2011. Vol. 185, no 3, 382-386 p.
Keyword [en]
Monoamine oxidase, Psychopathology, Antisocial personality disorder, Borderline personality disorder, Personality inventory, Violent crimes, Alcoholism
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URN: urn:nbn:se:uu:diva-148471DOI: 10.1016/j.psychres.2010.08.026ISI: 000287467200014PubMedID: 20850185OAI: oai:DiVA.org:uu-148471DiVA: diva2:402347
Available from: 2011-03-08 Created: 2011-03-07 Last updated: 2011-05-12Bibliographically approved

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