Synthesis of estradiol backbone mimics via the Stille reaction using copper(II) oxide as co-reagent
2011 (English)In: Tetrahedron Letters, ISSN 0040-4039, E-ISSN 1873-3581, Vol. 52, no 2, 209-211 p.Article in journal (Refereed) Published
Sterically hindered biaryls and 2-phenylbenzo[b]thiophenes that can serve as templates for mimics of the estradiol backbone were prepared in modest to good yields by the Stille reaction using CuO as a co-reagent. Due to the neutral conditions applied in the Stille reaction, protection strategies were unnecessary for hydroxy containing coupling partners. Ligandless coupling conditions were also evaluated.
Place, publisher, year, edition, pages
2011. Vol. 52, no 2, 209-211 p.
IdentifiersURN: urn:nbn:se:uu:diva-148465DOI: 10.1016/j.tetlet.2010.10.144ISI: 000286789300010OAI: oai:DiVA.org:uu-148465DiVA: diva2:402355