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Bone metabolism analyzed by PET and DXA following revision THA using a distally fixed stem: A pilot study
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm , Centre for Research and Development, Gävleborg.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Radiology, Oncology and Radiation Science, Section of Nuclear Medicine and PET.
2011 (English)In: HIP International, ISSN 1120-7000, E-ISSN 1724-6067, Vol. 21, no 1, 30-38 p.Article in journal (Refereed) Published
Abstract [en]

In a pilot study we analyzed bone remodeling using F-18-PET (positon emission tomography) scanning or DXA (dual-energy x-ray absorptiometry) in 3 patient groups, one with a loose femoral stem and 2 after revision using a modular stem (MP). In loose implants (group 1), bone formation activity compared to the contralateral healthy femur was 261 %. In the proximal part of the femur bone formation was increased by 253 % one week after revision (group 2) and did not normalize within 1 year. In the distal region it decreased to normal after one year. In the second revision group DXA showed decreased bone mineral density at 6 and 24 months (group 3). The PET technique provided evidence of bone healing despite osteolysis and prosthetic loosening which continued after revision. Decreasing BMD after revision in the third group is multifactorial, but suggests that despite intensive bone formation resorption was still higher.

Place, publisher, year, edition, pages
2011. Vol. 21, no 1, 30-38 p.
Keyword [en]
DXA, Osteolysis, Positron emission tomography, Revision, RSA, Total hip arthroplasty
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-148618DOI: 10.5301/HIP.2011.6304ISI: 000287485500005PubMedID: 21298623OAI: oai:DiVA.org:uu-148618DiVA: diva2:402454
Available from: 2011-03-08 Created: 2011-03-08 Last updated: 2017-12-11Bibliographically approved

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Ullmark, GöstaSörensen, Jens

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