uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Lateral superior olive function in congenital deafness
Show others and affiliations
2011 (English)In: Hearing Research, ISSN 0378-5955, E-ISSN 1878-5891, Vol. 277, no 1-2, 163-175 p.Article in journal (Refereed) Published
Abstract [en]

The development of cochlear implants for the treatment of patients with profound hearing loss has advanced considerably in the last few decades, particularly in the field of speech comprehension. However, attempts to provide not only sound decoding but also spatial hearing are limited by our understanding of circuit adaptations in the absence of auditory input. Here we investigate the lateral superior olive (LSO), a nucleus involved in interaural level difference (ILD) processing in the auditory brainstem using a mouse model of congenital deafness (the dn/dn mouse). An electrophysiological investigation of principal neurons of the LSO from the dn/dn mouse reveals a higher than normal proportion of single spiking (SS) neurons, and an increase in the hyperpolarisation-activated I(h) current. However, inhibitory glycinergic input to the LSO appears to develop normally both pre and postsynaptically in dn/dn mice despite the absence of auditory nerve activity. In combination with previous electrophysiological findings from the dn/dn mouse, we also compile a simple Hodgkin and Huxley circuit model in order to investigate possible computational deficits in ILD processing resulting from congenital hearing loss. We find that the predominance of SS neurons in the dn/dn LSO may compensate for upstream modifications and help to maintain a functioning ILD circuit in the dn/dn mouse. This could have clinical repercussions on the development of stimulation paradigms for spatial hearing with cochlear implants.

Place, publisher, year, edition, pages
2011. Vol. 277, no 1-2, 163-175 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-148679DOI: 10.1016/j.heares.2011.01.012ISI: 000293726600019PubMedID: 21276842OAI: oai:DiVA.org:uu-148679DiVA: diva2:402715
Available from: 2011-03-09 Created: 2011-03-09 Last updated: 2015-07-23Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Leão, Richardson N
By organisation
Department of Neuroscience
In the same journal
Hearing Research
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 203 hits
ReferencesLink to record
Permanent link

Direct link