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Dietary acrylamide intake and risk of colorectal cancer in a prospective cohort of men
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm , Centre for Clinical Research, County of Västmanland.
2009 (English)In: European Journal of Cancer, ISSN 0959-8049, E-ISSN 1879-0852, Vol. 45, no 4, 513-516 p.Article in journal (Refereed) Published
Abstract [en]

Acrylamide is a probable human carcinogen that causes cancer at multiple sites in animal models. However, whether dietary acrylamide intake increases the risk of colorectal cancer in humans is unclear. We examined the association between dietary acrylamide intake and colorectal cancer incidence in the Cohort of Swedish Men, a population-based prospective cohort of 45 306 men who completed a food-freuency questionnaire at enrolment in 1997. During a mean follow-up of 9.3 years, we ascertained 676 incident colorectal cancer cases. Compared with the lowest quartile of acrylamide intake (<29.6 mu g/d), the multivariate rate ratios for the highest quartile (>= 41.7 mu g/d) were 0.95 (95% confidence interval (CI) 0.74-1.20) for colorectal cancer, 0.97 (95% CI 0.71-1.31) for colon cancer and 0.91 (95% CI 0.62-1.34) for rectal cancer. in conclusion, this study provides no evidence that dietary acrylamide in amounts typically consumed by Swedish men is associated with risk of colorectal cancer.

Place, publisher, year, edition, pages
2009. Vol. 45, no 4, 513-516 p.
Keyword [en]
Acrylamide, Colorectal cancer, Diet, Epidemiology, Prospective studies
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-148709DOI: 10.1016/j.ejca.2008.12.001ISI: 000264606100012PubMedID: 19121931OAI: oai:DiVA.org:uu-148709DiVA: diva2:402808
Available from: 2011-03-09 Created: 2011-03-09 Last updated: 2011-03-09Bibliographically approved

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