uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Chronic Treatment with Nanoparticles Exacerbate Hyperthermia Induced Blood-Brain Barrier Breakdown, Cognitive Dysfunction and Brain Pathology in the Rat: Neuroprotective Effects of Nanowired-Antioxidant Compound H-290/51
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Anaesthesiology and Intensive Care.
Show others and affiliations
2009 (English)In: Journal of Nanoscience and Nanotechnology, ISSN 1533-4880, Vol. 9, no 8, 5073-5090 p.Article in journal (Refereed) Published
Abstract [en]

The possibility that chronic exposure of nanoparticles may alter stress reaction and brain pathology following hyperthermia was examined in a rat model. Engineered nanoparticles from Ag or M Cu (approximate to 50-60 nm) were administered (30 mg/kg, i.p.) once daily for 1 week in young male rats. M On the 8th day these animals were subjected to 4 h heat stress at 38 degrees C in a BOD incubator. In these animals stress symptoms, blood-brain barrier (BBB) permeability, cognitive and motor functions and brain pathology were examined. Subjection of nanoparticle treated rats to heat stress showed exacerbation of stress symptoms i.e., hyperthermia, salivation and prostration and exhibited greater BBB disruption, brain edema formation, impairment of cognitive and motor functions M and brain damage compared to normal animals. This enhanced brain pathology in heat stress was most marked in animals that received Ag nanoparticles compared to Cu treatment. Treatment with antioxidant compound H-290/51 either 30 min or 60 min after heat stress did not alter hyperthermia M induce brain pathology in nanoparticle treated rats. Whereas, administration of nanowired-H-290/51 after 30 min or 60 min heat stress markedly attenuated BBB disruption, sensory motor function and brain pathology. These results suggest that chronic nanoparticles treatment exacerbate hyperthermia induced brain pathology that is significantly attenuated by nanowired but not normal H-290/51 compound. Taken together, our observations suggest that nano-wired drug delivery of H-290/51 is a promising approach to induce neuroprotection in hyperthermia induced brain pathology, not reported earlier.

Place, publisher, year, edition, pages
2009. Vol. 9, no 8, 5073-5090 p.
Keyword [en]
Nanoparticles, Hyperthermia, Heat Stress, Antioxidants, H-290/51, Blood-Brain Barrier, Brain Edema, Brain Pathology, Nanowiring, Nano-Drug Delivery
National Category
Anesthesiology and Intensive Care
URN: urn:nbn:se:uu:diva-148799DOI: 10.1160/jnn.2009.GR10ISI: 000267994100072OAI: oai:DiVA.org:uu-148799DiVA: diva2:403370
Available from: 2011-03-12 Created: 2011-03-10 Last updated: 2012-03-15Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full text

Search in DiVA

By author/editor
Sharma, Hari Shanker
By organisation
Anaesthesiology and Intensive Care
In the same journal
Journal of Nanoscience and Nanotechnology
Anesthesiology and Intensive Care

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 198 hits
ReferencesLink to record
Permanent link

Direct link