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Adsorption behaviour of a quinidine carbamate-based chiral stationary phase: Role of the additive
Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Physical and Analytical Chemistry.
Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Physical and Analytical Chemistry.
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2009 (English)In: Journal of Chromatography A, ISSN 0021-9673, E-ISSN 1873-3778, Vol. 1216, no 16, 3480-3487 p.Article in journal (Refereed) Published
Abstract [en]

In this study, we incorporate the additive properties into the theoretical model of a general preparative chromatographic system; this is normally not done and this limits a proper process optimization. As a model phase system, we used the adsorption of 9H-fluoren-9-ylmethoxycarbonyl-allylglycine (Fmoc-allylglycine) enantiomers on a quinidine carbamate-based chiral stationary phase (anion exchanger) together with a methanol-glacial acetic acid-ammonium acetate eluent. The inverse method was used to measure the competitive adsorption isotherms of both the Fmoc-allylglycine enantiomers as well as the non-detectable additive acetic acid. It was concluded that this enantioselective preparative system is well described by a non-heterogeneous adsorption model and that the loading capacity is very high. The proposed model is valid over a wide range of additive concentrations, which is important for process optimization.

Place, publisher, year, edition, pages
2009. Vol. 1216, no 16, 3480-3487 p.
Keyword [en]
Chiral stationary phase, Quinidine carbamate-based chiral stationary phase, Chiral preparative chromatography, Adsorption isotherm data, Inverse method, Loadability
National Category
Chemical Sciences
Identifiers
URN: urn:nbn:se:uu:diva-148884DOI: 10.1016/j.chroma.2008.11.039ISI: 000265262300008PubMedID: 19062026OAI: oai:DiVA.org:uu-148884DiVA: diva2:403456
Available from: 2011-03-14 Created: 2011-03-11 Last updated: 2017-12-11Bibliographically approved

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