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Helicobacter pylori chromosomal DNA replication: Current status and future perspectives
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology, Microbiology.
2011 (English)In: FEBS Letters, ISSN 0014-5793, E-ISSN 1873-3468, Vol. 585, no 1, 7-17 p.Article, review/survey (Refereed) Published
Abstract [en]

Helicobacter pylori causes gastritis, gastric ulcer and gastric cancer. Though DNA replication and its control are central to bacterial proliferation, pathogenesis, virulence and/or dormancy, our knowledge of DNA synthesis in slow growing pathogenic bacteria like H. pylori is still preliminary. Here, we review the current understanding of DNA replication, replication restart and recombinational repair in H. pylori. Several differences have been identified between the H. pylori and Escherichia coli replication machineries including the absence of DnaC, the helicase loader usually conserved in gram-negative bacteria. These differences suggest different mechanisms of DNA replication at initiation and restart of stalled forks in H. pylori.

Place, publisher, year, edition, pages
2011. Vol. 585, no 1, 7-17 p.
Keyword [en]
Replication initiation, Elongation, Termination, Replication restart, Recombinational repair, Helicobacter pylori
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-148962DOI: 10.1016/j.febslet.2010.11.018ISI: 000285921500002OAI: oai:DiVA.org:uu-148962DiVA: diva2:403543
Available from: 2011-03-14 Created: 2011-03-14 Last updated: 2011-03-14Bibliographically approved

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