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Allopregnanolone, a GABA(A) receptor agonist, decreases gonadotropin levels in women: A preliminary study
Department of Clinical Science, Obstetrics and Gynaecology, Umeå University, Sweden.
Department of Clinical Science, Obstetrics and Gynaecology, Umeå University, Sweden.
Department of Clinical Science, Obstetrics and Gynaecology, Umeå University, Sweden.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health. (Reproduktiv hälsa/Sundström Poromaa)
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2011 (English)In: Gynecological Endocrinology, ISSN 0951-3590, E-ISSN 1473-0766, Vol. 27, no 12, 1087-1093 p.Article in journal (Refereed) Published
Abstract [en]

Animal studies suggest regulatory effects on the hypothalamic-pituitary-gonad axis by allopregnanolone, an endogenous gamma-aminobutyric acid A (GABA(A)) receptor agonist. Elevated levels of allopregnanolone in women with hypothalamic amenorrhea have been seen. Isoallopregnanolone is an isomer to allopregnanolone, but without GABA(A) receptor effects. The purpose of this study was to investigate effects of allopregnanolone and isoallopregnanolone on gonadotropin levels in healthy women of fertile age. Ten women were given allopregnanolone and five women isoallopregnanolone intravenously in follicular phase. Repeated blood samples were drawn during the test day. Main outcomes were changes in serum levels of follicle-stimulating hormone (FSH), luteinising hormone (LH), oestradiol, and progesterone. Serum-FSH decreased between 5 and 105 min after the allopregnanolone injection (F(16,144)=2.18, p=0.008). Serum-LH was reduced between 5 and 35 min following the allopregnanolone injection (F(16,144)=2.63, p=0.001). Serum-oestradiol and -progesterone were not significantly changed after allopregnanolone injections. No effect on gonadotropin levels were seen after administration of isoallopregnanolone. Allopregnanolone reduces FSH and LH levels in women and the effect might be mediated via a specific GABA(A) receptor activation since isoallopregnanolone lacked this effect. Although the number of women was small, the results suggest a regulatory mechanism on the hypothalamic-pituitary-gonadal axis by allopregnanolon.

Place, publisher, year, edition, pages
2011. Vol. 27, no 12, 1087-1093 p.
Keyword [en]
FSH, LH, GABA, allopregnanolone, isoallopregnanolone
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-148973DOI: 10.3109/09513590.2010.540603ISI: 000296777700026PubMedID: 21190418OAI: oai:DiVA.org:uu-148973DiVA: diva2:403562
Available from: 2011-03-14 Created: 2011-03-14 Last updated: 2017-12-11Bibliographically approved

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