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CT lung densitometry in young adults with alpha-1-antitrypsin deficiency
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences. (Uppsala University Hospital, Department of Emergency Medicine)
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2011 (English)In: Respiratory Medicine, ISSN 0954-6111, E-ISSN 1532-3064, Vol. 105, no 1, p. 74-79Article in journal (Refereed) Published
Abstract [en]

Background: Severe (PiZZ) and moderate (PiSZ) alpha-1-antitrypsin (AAT) deficiency predispose to lung emphysema, especially in smokers. We hypothesized that multi-slice computed tomography (CT) might be superior to pulmonary function tests (PFT) to detect lung emphysema in AAT-deficient individuals at the age of 32 years. Methods: A subgroup of PiZZ and PiSZ individuals identified during the Swedish newborn screening programme in 1972-74 underwent multi-slice CT and PFT at the age of 32 years. From the CT scans the percentile density at 15% (PD15) and the relative area below -910 Hounsfield Units (RA(-910) HU) were calculated. The results of PFT and CT were compared between the AAT-deficient individuals and an age-matched control group. Results: Twenty-five PiZZ, 11 PiSZ and 17 PiMM individuals participated in the study. All Pi subgroups had normal lung function. The mean PD15 was 81 (SD 22) g/L in the PiZZ individuals, 96 (SD 35) g/L in the PiSZ individuals and 79 (SD 17) g/L in the PiMM individuals (ns), and the RA-910 were 30 (SD 18)%, 24 (SD 20)%, and 32 (SD 18)%, respectively (ns). For the never-smoker subgroups, in the PiZZ (n = 23), PiSZ (n = 8) and PiMM (n = 12), the mean PD15 were 95 (SD 35) g/L, 81 (SD 22) g/L, and 75 (SD 12) g/L, respectively (ns). PD15 was significantly correlated to CT derived lung size (r = -0.72; p < 0.001). Conclusions: CT densitometry revealed no signs of emphysema and no differences between the AAT-deficient individuals identified by neonatal screening and age-matched control subjects.

Place, publisher, year, edition, pages
2011. Vol. 105, no 1, p. 74-79
Keywords [en]
Alpha-1-antitrypsin deficiency, CT densitometry, COPD, Emphysema, Screening
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-148987DOI: 10.1016/j.rmed.2010.06.016ISI: 000286863500012OAI: oai:DiVA.org:uu-148987DiVA, id: diva2:403674
Available from: 2011-03-14 Created: 2011-03-14 Last updated: 2017-12-11Bibliographically approved

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Bernspång, Elisabeth

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