uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Blood lipids in 75,048 type 2 diabetic patients: a population-based survey from the Swedish National diabetes register
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Geriatrics.
Show others and affiliations
2011 (English)In: European Journal of Cardiovascular Prevention & Rehabilitation, ISSN 1741-8267, E-ISSN 1741-8275, Vol. 18, no 1, 97-105 p.Article in journal (Refereed) Published
Abstract [en]

Background: Type 2 diabetes and diabetic dyslipidemia are high-risk conditions for cardiovascular disease. However, the description of the distribution of blood lipids in diabetic patients has not been based on population-based surveys. The aim of this study was to describe diabetic dyslipidemia in a large unselected sample of patients from the Swedish National Diabetes Register. Methods: Blood lipid profiles and clinical characteristics in 75,048 type 2 diabetic patients (57% men) were studied. Results: Pronounced hypertriglyceridemia (triglycerides >4.0mmol/l) was seen in 3.4% of the patients. Total cholesterol (TC), LDL-cholesterol (LDL-C), HDL-cholesterol (HDL-C) and non-HDL-C were generally higher, and LDL-C/HDL-C and Non-HDL-C/HDL-C ratios were lower in women. Mean TC, LDL-C as well as HDL-C values were lower in patients treated with lipid-lowering agents, whereas triglycerides was higher than in the untreated patients. In patients not treated with lipid-lowering agents all blood lipids increased in women and decreased in men (except HDL-C) at higher ages. Patients with LDL-C/HDL-C ratio >= 3 were slightly younger, less frequently used lipid-lowering drugs and had not so often a history of coronary heart disease or stroke. Conclusion: The distribution of blood lipids in this large sample of unselected type 2 diabetic patients challenges the previous conception of diabetic dyslipidemia, and calls for new studies to explain the roles of LDL-C and HDL-C as strong cardiovascular risk factors in type 2 diabetes.

Place, publisher, year, edition, pages
2011. Vol. 18, no 1, 97-105 p.
Keyword [en]
Blood lipids, cholesterol, epidemiology, high-density lipoprotein-cholesterol, low-density lipoprotein-cholesterol, triglycerides, type 2 diabetes
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-149036DOI: 10.1097/HJR.0b013e32833ba61eISI: 000287780400011PubMedID: 21354969OAI: oai:DiVA.org:uu-149036DiVA: diva2:403896
Available from: 2011-03-15 Created: 2011-03-15 Last updated: 2012-03-30Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Zethelius, BjörnCederholm, Jan
By organisation
GeriatricsFamily Medicine and Preventive Medicine
In the same journal
European Journal of Cardiovascular Prevention & Rehabilitation
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 146 hits
ReferencesLink to record
Permanent link

Direct link